A 45-year-old man experiences dry mouth and constipation. Which medicine should be avoided?

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Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

A 45-year-old man experiences dry mouth and constipation. Which medicine should be avoided?

Explanation:
Dry mouth and constipation point to anticholinergic (antimuscarinic) side effects, which happen when a drug blocks acetylcholine at muscarinic receptors and reduces secretions while slowing gut motility. Glycopyrronium bromide is an anticholinergic bronchodilator, so it commonly causes dry mouth and constipation. Because these symptoms reflect the drug’s mechanism, this medicine should be avoided in someone presenting with them. The other options do not have strong anticholinergic effects: salbutamol mainly causes tremor and tachycardia, fluticasone can cause oral thrush, and montelukast has different adverse effects with no prominent xerostomia or constipation.

Dry mouth and constipation point to anticholinergic (antimuscarinic) side effects, which happen when a drug blocks acetylcholine at muscarinic receptors and reduces secretions while slowing gut motility. Glycopyrronium bromide is an anticholinergic bronchodilator, so it commonly causes dry mouth and constipation. Because these symptoms reflect the drug’s mechanism, this medicine should be avoided in someone presenting with them. The other options do not have strong anticholinergic effects: salbutamol mainly causes tremor and tachycardia, fluticasone can cause oral thrush, and montelukast has different adverse effects with no prominent xerostomia or constipation.

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