A patient started on clopidogrel asks which medicine is most likely to interact with the therapy?

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Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

A patient started on clopidogrel asks which medicine is most likely to interact with the therapy?

Explanation:
Clopidogrel is a prodrug that must be activated by liver enzymes, especially CYP2C19, to become effective at preventing platelets from clumping. When combined with a drug that inhibits CYP2C19, like omeprazole, clopidogrel’s activation is reduced, leading to lower antiplatelet activity and a potentially higher risk of thrombotic events. The other medications listed do not meaningfully inhibit CYP2C19 or affect clopidogrel’s activation, so they are less likely to interact in this way.

Clopidogrel is a prodrug that must be activated by liver enzymes, especially CYP2C19, to become effective at preventing platelets from clumping. When combined with a drug that inhibits CYP2C19, like omeprazole, clopidogrel’s activation is reduced, leading to lower antiplatelet activity and a potentially higher risk of thrombotic events. The other medications listed do not meaningfully inhibit CYP2C19 or affect clopidogrel’s activation, so they are less likely to interact in this way.

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