A pregnant woman requests directions for fusidic acid 2% cream to treat non-bullous impetigo on the legs and asks if it's safe in pregnancy. Which is the most appropriate advice regarding dosing?

• A. Apply the cream once daily for seven days.
• B. Apply the cream twice daily for five to seven days.
• C. Apply the cream every 6 hours for five days.
• D. Apply the cream three times daily for five to seven days.

Answer: (D)

The key point is keeping the antibiotic concentration on the skin consistently high enough to eradicate the bacteria for the duration of the infection. For non-bullous impetigo treated with fusidic acid 2% cream, the best regimen is to apply it to the affected area three times a day for five to seven days. This frequency maintains regular topical exposure to the bacteria, helping clear the infection within a standard course without unnecessary prolongation that could drive resistance.

In pregnancy, topical fusidic acid is generally considered safe when used as directed because systemic absorption is minimal, but it should be used for the shortest effective duration and with proper technique (thin layer, non-occlusive, and clean hands). If symptoms persist or worsen, seek further advice.