After initiating clozapine, what is the recommended blood count monitoring frequency?

• A. Weekly for the first 18 weeks
• B. Biweekly for 8 weeks
• C. Daily
• D. Monthly thereafter

Answer: (A)

Clozapine carries a risk of agranulocytosis, so blood counts must be checked frequently when starting treatment to catch neutropenia early. The period of greatest risk is the initial weeks after initiation, which is why the recommended plan uses frequent monitoring early on. Checking the full blood count weekly for about 18 weeks provides timely detection of any drop in neutrophils and allows prompt action if needed. After this intensive phase, the frequency is reduced as the risk stabilizes, with later monitoring typically becoming biweekly and then monthly depending on guidelines. This approach prioritizes patient safety while enabling continued treatment when counts remain stable.