Alteplase works as a fibrinolytic by which mechanism?

Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

Alteplase works as a fibrinolytic by which mechanism?

Explanation:
Alteplase is a tissue-type plasminogen activator. Its action is to bind to a clot and convert plasminogen that’s near and on the fibrin into plasmin. Plasmin then digests fibrin and dissolves the clot. This targeted activation of plasminogen explains why the correct option is converting plasminogen to plasmin. It’s not about inhibiting platelets or thrombin, and it’s not simply activating plasminogen directly in solution without the fibrin context.

Alteplase is a tissue-type plasminogen activator. Its action is to bind to a clot and convert plasminogen that’s near and on the fibrin into plasmin. Plasmin then digests fibrin and dissolves the clot. This targeted activation of plasminogen explains why the correct option is converting plasminogen to plasmin. It’s not about inhibiting platelets or thrombin, and it’s not simply activating plasminogen directly in solution without the fibrin context.

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