Can a man taking ritonavir for HIV be supplied sildenafil OTC?

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Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

Can a man taking ritonavir for HIV be supplied sildenafil OTC?

Explanation:
Ritonavir strongly inhibits the enzyme that metabolizes sildenafil, causing sildenafil levels in the body to rise dramatically. This makes the risk of adverse effects—especially low blood pressure, dizziness, fainting, and potentially priapism—much higher. Because of this significant interaction, sildenafil should not be supplied over the counter to someone taking ritonavir; it is contraindicated and needs medical evaluation. If ED treatment is needed in this context, it should be discussed with a clinician who can review the HIV therapy and consider safer options under supervision.

Ritonavir strongly inhibits the enzyme that metabolizes sildenafil, causing sildenafil levels in the body to rise dramatically. This makes the risk of adverse effects—especially low blood pressure, dizziness, fainting, and potentially priapism—much higher. Because of this significant interaction, sildenafil should not be supplied over the counter to someone taking ritonavir; it is contraindicated and needs medical evaluation. If ED treatment is needed in this context, it should be discussed with a clinician who can review the HIV therapy and consider safer options under supervision.

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