In a patient with deep vein thrombosis and a creatinine clearance of 35 mL/min, what rivaroxaban dose is most appropriate?

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Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

In a patient with deep vein thrombosis and a creatinine clearance of 35 mL/min, what rivaroxaban dose is most appropriate?

Explanation:
Renal function affects rivaroxaban exposure, so the dose must be adjusted when kidney clearance is reduced. With a creatinine clearance of 35 mL/min, the patient has moderate renal impairment, and the maintenance dose for DVT treatment is lowered to reduce bleeding risk while maintaining efficacy. The 15 mg once daily dose achieves this balance in this renal function range, whereas the standard full dose would increase bleeding risk, and the other listed options are either subtherapeutic or not an approved dose.

Renal function affects rivaroxaban exposure, so the dose must be adjusted when kidney clearance is reduced. With a creatinine clearance of 35 mL/min, the patient has moderate renal impairment, and the maintenance dose for DVT treatment is lowered to reduce bleeding risk while maintaining efficacy. The 15 mg once daily dose achieves this balance in this renal function range, whereas the standard full dose would increase bleeding risk, and the other listed options are either subtherapeutic or not an approved dose.

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