Lisinopril can potentiate the hypotensive effect of GTN. Which option lists this as the correct drug?

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Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

Lisinopril can potentiate the hypotensive effect of GTN. Which option lists this as the correct drug?

Explanation:
The question tests understanding of additive vasodilatory interactions. Lisinopril is an ACE inhibitor; it lowers blood pressure by inhibiting angiotensin II–mediated vasoconstriction, reducing systemic vascular resistance. Glyceryl trinitrate (nitroglycerin) dilates blood vessels by releasing nitric oxide, lowering both preload and afterload. When these two are used together, their vasodilatory effects compound, potentially producing a stronger drop in blood pressure than either alone. That’s why lisinopril can potentiate the hypotensive effect of GTN. The other drugs listed don’t have this specific interaction with GTN: digoxin mainly affects cardiac contractility and conduction, bisoprolol is a beta-blocker with different interaction concerns, and simvastatin is a lipid-lowering agent with no notable additive hypotensive interaction with GTN. Monitor for dizziness or fainting if these are co-administered.

The question tests understanding of additive vasodilatory interactions. Lisinopril is an ACE inhibitor; it lowers blood pressure by inhibiting angiotensin II–mediated vasoconstriction, reducing systemic vascular resistance. Glyceryl trinitrate (nitroglycerin) dilates blood vessels by releasing nitric oxide, lowering both preload and afterload. When these two are used together, their vasodilatory effects compound, potentially producing a stronger drop in blood pressure than either alone. That’s why lisinopril can potentiate the hypotensive effect of GTN. The other drugs listed don’t have this specific interaction with GTN: digoxin mainly affects cardiac contractility and conduction, bisoprolol is a beta-blocker with different interaction concerns, and simvastatin is a lipid-lowering agent with no notable additive hypotensive interaction with GTN. Monitor for dizziness or fainting if these are co-administered.

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