Vincristine sulfate is administered by which route?

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Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

Vincristine sulfate is administered by which route?

Explanation:
Vincristine must reach the bloodstream in a controlled way to be effective, so it is given intravenously. Oral use is not reliable because the drug has poor and unpredictable bioavailability, meaning you wouldn’t get a consistent systemic exposure. It’s also a vesicant, so extravasation from a peripheral injection can cause severe tissue necrosis, making IV administration with proper technique essential. Subcutaneous or intramuscular routes are avoided due to unpredictable absorption and a higher risk of local injury. Therefore, intravenous administration is the appropriate route.

Vincristine must reach the bloodstream in a controlled way to be effective, so it is given intravenously. Oral use is not reliable because the drug has poor and unpredictable bioavailability, meaning you wouldn’t get a consistent systemic exposure. It’s also a vesicant, so extravasation from a peripheral injection can cause severe tissue necrosis, making IV administration with proper technique essential. Subcutaneous or intramuscular routes are avoided due to unpredictable absorption and a higher risk of local injury. Therefore, intravenous administration is the appropriate route.

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