What is the clinical difference between Clenil modulate and Qvar?

• A. Qvar is more potent than Clenil
• B. Both have the same potency
• C. Clenil is twice as potent as Qvar
• D. Qvar is twice as potent as Clenil

Answer: (D)

The key idea is that potency depends not just on the drug, but also on how it’s delivered to the lungs. Qvar uses beclomethasone dipropionate in an HFA propellant, which creates a finer particle size and better deposition in the airways. This makes it about twice as potent per microgram as Clenil Modulite. Clinically, this means the same anti-inflammatory effect is achieved with roughly half the inhaled micrograms when using Qvar compared with Clenil Modulite. In practice, switching between them requires dose adjustments to maintain control and minimize systemic exposure, reflecting the different delivery efficiency rather than a change in the drug’s intrinsic activity.