What is the maximum recommended daily dose of paracetamol for adults?

• A. 3 g per day
• B. 4 g per day
• C. 2 g per day
• D. 5 g per day

Answer: (B)

The maximum daily dose for adults with normal liver function is 4 g (4000 mg). This limit helps prevent liver toxicity because paracetamol is processed in the liver into a reactive metabolite (NAPQI); when taken at high amounts, glutathione stores can be depleted and NAPQI accumulates, risking serious liver injury. To stay within safe bounds, keep total intake from all paracetamol-containing products under 4 g in a 24-hour period and space doses 4–6 hours apart, typically 500–1000 mg per dose. Be mindful that many cold, flu, or combination medicines also contain paracetamol, which can quietly push the total over the limit. In certain groups—such as those with chronic alcohol use, malnutrition, liver disease, or elderly patients with frailty—consider a lower daily limit and consult guidelines, but for a healthy adult the 4 g/day ceiling is the standard maximum.