What is the recommended dosing guidance for a second dose of sumatriptan if the migraine recurs?

• A. Take a second 50 mg after 2 hours if the migraine recurs, up to 300 mg in 24 hours
• B. Take a second 50 mg after 4 hours, up to 200 mg in 24 hours
• C. Take a second 50 mg after 1 hour, up to 100 mg in 24 hours
• D. Take a second 50 mg after 6 hours, up to 150 mg in 24 hours

Answer: (A)

When using sumatriptan 50 mg for an acute migraine, you may take a second 50 mg dose if the migraine recurs, but only after at least 2 hours have passed since the first dose. The total amount in 24 hours should not exceed 300 mg. This timing lets you assess response to the first dose and provides a safety buffer to limit cardiovascular and other adverse effects from sumatriptan. The other options propose incorrect intervals or lower daily limits that don’t match standard dosing guidance for this tablet strength. If recurrences are frequent, discuss with a clinician for further management.