Which condition is a contraindication for spironolactone?

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Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

Which condition is a contraindication for spironolactone?

Explanation:
Spironolactone is a potassium-sparing diuretic that blocks aldosterone in the collecting ducts, reducing potassium excretion and raising potassium levels. Because of this, it is contraindicated if potassium is already high, since further increases can cause dangerous heart rhythm problems. The other conditions listed do not by themselves mandate avoiding spironolactone; they may require caution or monitoring, but hyperkalemia is the specific situation that makes this drug unsafe.

Spironolactone is a potassium-sparing diuretic that blocks aldosterone in the collecting ducts, reducing potassium excretion and raising potassium levels. Because of this, it is contraindicated if potassium is already high, since further increases can cause dangerous heart rhythm problems. The other conditions listed do not by themselves mandate avoiding spironolactone; they may require caution or monitoring, but hyperkalemia is the specific situation that makes this drug unsafe.

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