Which drug is NOT known to exacerbate psoriasis?

• A. Amlodipine
• B. Lithium
• C. Beta-blockers
• D. Hydrochlorothiazide

Answer: (A)

The main idea is that some medicines can worsen psoriasis by nudging the skin’s inflammatory pathways and keratinocyte growth. Lithium is a classic trigger because it promotes epidermal proliferation, leading to plaque worsening. Beta-blockers can alter immune signaling in the skin and may worsen inflammation. Thiazide diuretics, like hydrochlorothiazide, have been linked to flares, possibly through dehydration or other immune effects that favor psoriatic activity. Amlodipine, a calcium channel blocker, does not have a recognized association with triggering psoriasis in ordinary clinical experience; its action targets vascular smooth muscle without prominently driving the skin inflammatory processes that fuel psoriasis. So amlodipine is not known to exacerbate psoriasis, whereas the others are linked to worsening in some patients.