Which factor can potentiate the hypotensive effect of GTN?

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Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

Which factor can potentiate the hypotensive effect of GTN?

Explanation:
GTN lowers blood pressure by releasing nitric oxide, causing vasodilation and reduced preload and afterload. Alcohol adds to this effect because it also causes peripheral vasodilation and can blunt reflex compensatory responses, so the combination can produce a greater drop in blood pressure. Paracetamol and ibuprofen don’t enhance nitrate-induced vasodilation, and caffeine tends to raise BP rather than potentiate hypotension, making alcohol the factor that can potentiate GTN’s hypotensive effect.

GTN lowers blood pressure by releasing nitric oxide, causing vasodilation and reduced preload and afterload. Alcohol adds to this effect because it also causes peripheral vasodilation and can blunt reflex compensatory responses, so the combination can produce a greater drop in blood pressure. Paracetamol and ibuprofen don’t enhance nitrate-induced vasodilation, and caffeine tends to raise BP rather than potentiate hypotension, making alcohol the factor that can potentiate GTN’s hypotensive effect.

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