Which of the following is most likely a side effect of lisinopril therapy?

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Multiple Choice

Which of the following is most likely a side effect of lisinopril therapy?

Explanation:
ACE inhibitors like lisinopril commonly cause a dry, persistent cough. This happens because these drugs block the enzyme that breaks down bradykinin, so bradykinin accumulates in the respiratory tract and can trigger coughing. The cough is usually nonproductive and can begin after weeks to months of therapy, often resolving if the medication is stopped or if a switch is made to a different class such as an ARB. Diarrhea, insomnia, and tinnitus are not typical or characteristic side effects of lisinopril, making the cough the most likely adverse effect.

ACE inhibitors like lisinopril commonly cause a dry, persistent cough. This happens because these drugs block the enzyme that breaks down bradykinin, so bradykinin accumulates in the respiratory tract and can trigger coughing. The cough is usually nonproductive and can begin after weeks to months of therapy, often resolving if the medication is stopped or if a switch is made to a different class such as an ARB. Diarrhea, insomnia, and tinnitus are not typical or characteristic side effects of lisinopril, making the cough the most likely adverse effect.

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