Which of the following is a classic symptom of phenytoin overdose?

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Multiple Choice

Which of the following is a classic symptom of phenytoin overdose?

Explanation:
Nystagmus is the classic sign of phenytoin overdose because phenytoin at toxic levels particularly disrupts cerebellar and vestibular control of eye movements. This leads to rhythmic, involuntary eye movements that often appear early in toxicity. While ataxia, diplopia, and confusion can also occur with higher levels, nystagmus is the most characteristic and commonly described early indicator of phenytoin toxicity, making it the best answer.

Nystagmus is the classic sign of phenytoin overdose because phenytoin at toxic levels particularly disrupts cerebellar and vestibular control of eye movements. This leads to rhythmic, involuntary eye movements that often appear early in toxicity. While ataxia, diplopia, and confusion can also occur with higher levels, nystagmus is the most characteristic and commonly described early indicator of phenytoin toxicity, making it the best answer.

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