Which of the following is NOT a hormone therapy for prostate cancer?

• A. Androgen deprivation therapy
• B. Chemotherapy
• C. Radiotherapy
• D. Anastrozole

Answer: (D)

Prostate cancer growth is driven by androgens, so therapies that reduce androgen production or block its effect are considered hormone therapies. Androgen deprivation therapy directly targets this axis by lowering testosterone or blocking its action. Anastrozole, on the other hand, is an aromatase inhibitor that lowers estrogen levels. While this is a hormonal mechanism, it is not a standard approach for prostate cancer, because estrogen suppression is not the main or proven strategy to control PCa growth. Chemotherapy and radiotherapy do not work by altering hormone signaling; they treat cancer through cytotoxic effects or localized tissue destruction. Therefore, Anastrozole is not used as a hormone therapy for prostate cancer.