Which of the following is NOT a sign of liver toxicity in a patient taking methotrexate?

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Multiple Choice

Which of the following is NOT a sign of liver toxicity in a patient taking methotrexate?

Explanation:
Methotrexate can cause liver toxicity that shows up as elevated liver enzymes and signs of bilirubin buildup, such as dark urine, along with gastrointestinal symptoms like abdominal discomfort, nausea, and vomiting. Dark stools are not a typical indicator of MTX-related liver injury; stool color reflects bile pigment delivery to the gut and, in liver or biliary disease, stools are more likely to be pale if bile flow is blocked. So the sign that does not reflect hepatic toxicity in this context is dark stools.

Methotrexate can cause liver toxicity that shows up as elevated liver enzymes and signs of bilirubin buildup, such as dark urine, along with gastrointestinal symptoms like abdominal discomfort, nausea, and vomiting. Dark stools are not a typical indicator of MTX-related liver injury; stool color reflects bile pigment delivery to the gut and, in liver or biliary disease, stools are more likely to be pale if bile flow is blocked. So the sign that does not reflect hepatic toxicity in this context is dark stools.

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