Which statement about vitamin K-rich foods and warfarin is true?

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Study for the Foundation Year Pharmacy – Clinical Practice Test. Prepare with detailed questions, step-by-step explanations, and test format insights. Enhance your readiness and confidence!

Multiple Choice

Which statement about vitamin K-rich foods and warfarin is true?

Explanation:
Warfarin reduces the production of vitamin K–dependent clotting factors, so the level of anticoagulation is tracked by the INR. When you consume vitamin K–rich foods, you supply more vitamin K, which replenishes those factors and counteracts warfarin’s effect. This tends to lower the INR, meaning less anticoagulation. So vitamin K–rich foods can decrease warfarin’s effect by reducing INR. The other statements don’t fit: higher INR would come from less vitamin K, and while intake can influence INR, the direction is predictable rather than truly unpredictable when intake is considered.

Warfarin reduces the production of vitamin K–dependent clotting factors, so the level of anticoagulation is tracked by the INR. When you consume vitamin K–rich foods, you supply more vitamin K, which replenishes those factors and counteracts warfarin’s effect. This tends to lower the INR, meaning less anticoagulation. So vitamin K–rich foods can decrease warfarin’s effect by reducing INR. The other statements don’t fit: higher INR would come from less vitamin K, and while intake can influence INR, the direction is predictable rather than truly unpredictable when intake is considered.

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