Which statement best describes how ciclosporin oral solution should be administered to reduce variability in absorption?

• A. Oral liquid doses can be mixed with soft drinks before administration
• B. Take with a glass of milk
• C. Take on an empty stomach with no liquids
• D. Mix with orange juice and wait 15 minutes

Answer: (A)

Ciclosporin oral solution has highly variable absorption, so the best way to reduce that variability is to ensure the full, intended dose is swallowed promptly and consistently. Mixing the liquid with a soft drink helps mask the taste and makes it easier to swallow the entire dose quickly, reducing the chance of incomplete dosing or delays that can alter how much is absorbed. Other methods—such as taking with a milk fat content, taking on an empty stomach with no liquids, or mixing with juice and waiting—can change gastric conditions or delay ingestion, introducing more variability in absorption.