Which statement best describes sequential hormone replacement therapy?

• A. Estrogen and progestogen given in cycle-like fashion
• B. Estrogen alone continuously
• C. Progestin alone
• D. Testosterone with estrogen

Answer: (A)

In sequential HRT, estrogen is given continuously while a progestogen is added during part of the cycle to mimic the natural menstrual pattern. The progestogen is used for a set number of days each cycle, providing endometrial protection against estrogen’s proliferative effects and often producing a withdrawal bleed. That cycle-like regimen is what the statement describes.

This fits because it combines estrogen with progestogen in a cyclical fashion, which is the hallmark of sequential HRT. In contrast, estrogen alone continuously would be continuous HRT without a progestogen and endometrial protection; progestin alone wouldn’t address menopausal symptoms with estrogen; and a mix like testosterone with estrogen isn’t the standard sequential regimen for menopausal symptom management.